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1.
Artigo em Inglês | MEDLINE | ID: mdl-35742454

RESUMO

This paper presents a review of the research carried out internationally in recent years regarding textbooks, teaching materials, and the field of physical education. The objectives to which this article aims are as follows: To offer a compilation of current research papers published in the Scopus, Web of Science, and Dialnet databases and to provide a classification of the research lines undertaken on the subject. The information used is based on a review of studies listed in Scopus, Web of Science, and Dialnet. For this, a systematic review was carried out with the terms: "curricular resources", "didactic materials", "digital resources", "educational resource", "physical education", and "textbooks", allowing the selection of original articles, which included information on this line of research. For the literature review, only articles that presented scientific evidence were used, discarding merely descriptive articles or didactic experiences that were not investigated with the scientific protocol. A total of 589 articles were found, although after applying the review's inclusion criteria, they were reduced to 54 articles. The investigations do not follow a common protocol and the researchers address multiple objectives in them, highlighting the studies on the implicit ideological discourse in the images of physical education textbooks. The results reveal a diversity of research, in particular, studies involving ideological discourse. Insofar as methodology, content analysis of textbooks and materials was the most common approach.


Assuntos
Aprendizagem , Educação Física e Treinamento , Competência Clínica
2.
Nanomaterials (Basel) ; 9(7)2019 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-31261957

RESUMO

Paclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to specifically treat cancer cells that overexpress the human epidermal growth factor receptor-2 (HER2). METHODS: Alginate and piperazine nanoparticles were synthetized and conjugated with paclitaxel:ß-cyclodextrins complexes and trastuzumab. Conjugated nanoparticles (300 nm) were characterized and their internalization in HER2-overexpressing tumor cells was analyzed by immunofluorescence. Its specific antitumor activity was studied in vitro using human cell lines with different levels of HER2-expression. RESULTS: In comparison with free paclitaxel:ß-cyclodextrins complexes, the developed conjugated nanovehicle presented specificity for the treatment of HER2-overpressing cells, in which it was internalized by endocytosis. CONCLUSIONS: It seems that potentially avoiding the conventional adverse effects of paclitaxel treatment could be possible with the use of the proposed mixed nanovehicle, which improves its bioavailability and targets HER2-positive cancer cells.

4.
Med. reabil ; 27(2): 62-66, maio-ago. 2008. ilus
Artigo em Espanhol | LILACS | ID: lil-490331

RESUMO

Objectivo: Determinar la influencia de un sistema de actividades encaminadas a mejorar la escritura de pacientes con disgrafía motora secuelar a una lesión estáticas del sistema nervioso central. Métodos: Se realizó un estudio cuasi-experimental con 20 pacientes con secuelas de accidente cerebro vascular o trauma cráneo encefálico. La muestra tenía como características comunes hemiparesia como defecto motor, un tiempo de evolución de la enfermedad de 6 meses a 5 años y dificultades para ejecutar correctamente el lenguage escrito sin la presencia de afasias. Se aplicó la escala OLIGRAF como protocolo de evaluación y el paquete estadístico SPSS para comparar los resultados iniciales y finales. Resultados: Los pacientes mejoraron considerablemente. Los resultados obtenidos en la media y la desviación estándar demostraron mejorías significativas. Conclusiones: El sistema de actividades aplicado influyó de forma positiva en el logro de los objetivos propuestos.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Agrafia/reabilitação , Paresia , Transtornos Cerebrovasculares/complicações , Lesões Encefálicas Traumáticas/complicações
5.
Metas enferm ; 9(1): 16-18, feb. 2006.
Artigo em Es | IBECS | ID: ibc-044197

RESUMO

Partiendo del desarrollo de las distintas disciplinas relacionadas conla salud, se analizan las condiciones para una verdadera interdisciplinaridad,que pasa por una total autonomía y desarrollo de cadauna de las disciplinas como prerrequisito para que, a través de unlenguaje traductor, se dé cuenta de cada uno de los aspectos delcomún objeto de estudio y haga posible un mutuo entendimientoy colaboración entre dichos saberes


Taking the development of different health-related disciplines as thestarting point, the conditions for true interdisciplinarity are analysed.Such interdisciplinarity to exist requires full autonomy and developmentof each of the disciplines as a prerequisite so that, through a translatinglanguage, mental health teams become aware each and one of theaspects of the common subject of the study, making the mutual understandingand collaboration of both types of knowledge, possible


Assuntos
Humanos , Comunicação Interdisciplinar , Terminologia , Especialização/tendências , Relações Interprofissionais , Assistência Integral à Saúde/tendências , Comportamento Cooperativo
6.
Ann Thorac Surg ; 79(3): 974-9; discussion 979, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15734416

RESUMO

BACKGROUND: The accuracy of clinical staging in lung cancer may be evaluated by comparing it against the gold standard of pathologic staging. The objective of this paper is to compare these two staging methods in a series of 2,994 lung cancer cases operated on consecutively in Spain between 1993 and 1997. METHODS: The raw frequency of agreement was used to compare clinical against pathologic staging and to assess the agreement. Kappa's index was used to determine the random effect of agreement. RESULTS: Ninety-three percent of the entire population were men, with a mean age of 64 years (median, 66; SD, 9.6). The majority of cases were classified as squamous tumors (1,774; 59%), with complete resection (2,410; 80%), and with lobectomy or bilobectomy (1,490; 55%). The most frequently found pathologic stage was pIB (997; 37%), followed by pIIIA (524; 19%). Considering the 2,377 cases with clinical and pathologic staging data, a classification coincidence was observed in 1,108 cases (47%; Kappa's index 0.248 for stages IA through IIIB). Considering the pathologic staging as the gold standard, the agreement was 75% for stages IA-IB (Kappa's index 0.56). In general, downstaging is more frequent than upstaging. CONCLUSIONS: This recent series of lung cancer showed the low diagnostic accuracy of the clinical staging as compared with the pathologic staging. Diagnostic accuracy was found to be much higher in the initial IA-IB stages, as illustrated by Kappa's index.


Assuntos
Neoplasias Pulmonares/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Neoplasias Pulmonares/classificação , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Prospectivos
7.
Cir. Esp. (Ed. impr.) ; 73(3): 191-193, mar. 2003. ilus
Artigo em Es | IBECS | ID: ibc-19837

RESUMO

Introducción. El neumotórax catamenial es una entidad poco frecuente, que desde su descripción en 1958 ha planteado dudas respecto a su etiología. Esto resulta trascendental si se pretende aportar el tratamiento más idóneo, especialmente si se tiene en cuenta que dada su escasa frecuencia de aparición no permite acumular gran experiencia individual. Objetivo. Nuestro trabajo tiene un doble objetivo: en primer lugar, exponer de forma clara y concisa las hipótesis etiopatológicas planteadas por los distintos autores, así como las diferentes opciones terapéuticas ensayadas y sus resultados. En segundo lugar, aportar un caso tratado en nuestro servicio, que por su evolución permite, en opinión de los autores, sopesar la importancia de las distintas hipótesis etiológicas.Conclusiones. Se han descrito tres teorías fisiopatológicas para explicar el origen de un neumotórax que aparece en relación con la menstruación. La primera de las hipótesis se basa en la existencia de tejido ectópico endometrial en la pleura. La segunda teoría atribuye el origen del aire a la cavidad abdominal, dada la existencia de fenestraciones diafragmáticas, que permitirían el paso de aire al tórax desde la cavidad abdominal. La tercera hipótesis propone la roptura de blebs pulmonares debido a los cambios hormonales que tienen lugar en este período del ciclo menstrual. En el caso que aportamos, se encontraron evidencias para sustentar al menos dos de las hipótesis propuestas, demostrando, en nuestra opinión, un origen multifactorial del proceso que requiere un tratamiento quirúrgico asociado posteriormente a un tratamiento hormonal (AU)


Assuntos
Feminino , Pessoa de Meia-Idade , Humanos , Pneumotórax/etiologia , Endometriose/complicações , Terapia de Reposição Hormonal , Pneumotórax/cirurgia , Pneumotórax , Pneumotórax/tratamento farmacológico , Radiografia Torácica , Pleura , Toracotomia , Distúrbios Menstruais/complicações
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